Folic acid antagonists have similar effects and may increase the incidence of hematologic reactions. It can cause serious sideeffects, such as anemia, which must be closely monitored during treatment. My doctor told me to start dapsone this week started a low dose on monday. Call your childs doctor or get medical help if any of these side effects or any other side effects bother your child or do not go away. Know dapsone uses, side effects, dosage, contraindications, benefit, interactions, purpose, drug interactions, precautions, warnings only on practo. Dapsone 100mg tablet is available both topically and by mouth. Drug information on aczone dapsone topical includes side effects, uses, drug interactions, dosage, drug pictures, overdose symptoms, and what to avoid. Itching, dryness, redness, scaling, or peeling of the skin, or loss of hair. Dapsone is an effective drug for the management of patients with some blistering disease, especially those with predominant neutrophilic infiltrates in the skin. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away. It was found to be the most effective initial agent for active or acute ocp and a safer treatment in the elderly than steroids and immunosuppressants. Dapsone was first studied as an antibiotic in 1937.
In some cases the medication may need to be taken for many more months or years. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them. Patients deficient in glucose6phosphate dehydrogenase, or methaemoglobin reductase, or with haemoglobin m are more susceptible to the haemolytic effects of dapsone. Dapsone should be stopped if allergy is suspected and medical advice sought. The drug is given as an alternative to people who can not tolerate the effects of dapsone for leprosy. Side effects of aczone gel dapsone, warnings, uses rxlist. Find patient medical information for dapsone oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. In the past, some authors suggested that dapsoneinduced psychosis oc curs only when high dosage and family history of. Dapsone 100mg tablet which is also known as diaminodiphenyl sulfone or dds for short, is an antibiotic which is commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. These side effects may go away during treatment as your body adjusts to the medicine.
Dapsone is a very effective drug and is a very good treatment for a number of. Dryness, redness, oiliness, or peeling at the application site. Clofazimine also has a marked antiinflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum enl. As with all medicines, some patients may experience side effects. Check with your physician immediately if you start having rash and fever, which could be signs of dapsone syndrome for leprosy treatment, dapsone can also cause eye or nerve damage if the condition is not monitored closely. Patients should be monitored for increased side effects. Dapsone sago 2002 dermatologic therapy wiley online. If they occur, most are likely to be minor and temporary. To make sure dapsone is safe for you, tell your doctor if you have. Patients on weekly pyrimethamine and dapsone have developed agranulocytosis during. Feb 06, 2020 dapsone is an antiinfective medicine that fights bacteria. Our aczone dapsone gel, 5% side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
A previously unrecognised side effect of dapsone british. Dapsone fda prescribing information, side effects and uses. Dapsone has several offlabel usesnamely, treatment of pneumocystis jiroveci pneumonia, bullous systemic lupus erythematosus, and severe aphthous ulcers. Topics az slideshows images quizzes supplements medications. Aczone dapsone gel, 5% is a sulfone drug indicated for the topical treatment of acne vulgaris. Dapsone 100mg tablet uses, side effects, substitutes. Most adverse reactions are dose related and uncommon at dosages up to 100 mg daily. Dapsone is an antibacterial antibiotic that blocks myeloperoxidase during inflammation. Common and rare side effects for dapsone oral webmd. Most patients who take dapsone do not have any problems but occasionally it can produce an upset stomach, diarrhea, headache, muscle cramps and skin rashes. Dapsone should be used with caution in patients with cardiac or pulmonary disease.
Dapsone avlosulfon aids information, education, action. Dapsone is a medication that is usually very well tolerated. Common dapsone side effects a study from fda data ehealthme. Dapsone was assessed for effects on perinatalpostnatal pup development and postnatal maternal behavior and function in a study in which dapsone was orally administered to female rats daily beginning on the seventh day of gestation and continuing until the twentyseventh day postpartum. Call your doctor for medical advice about side effects. This study is created by ehealthme based on reports of 6,679 people who have side effects when taking dapsone from food and drug administration fda, and is updated regularly. Although orally administered dapsone leads to high hepatic metabolism, decreasing the therapeutic index and causing severe side effects, this drug is an effective alternative for the treatment of pcp. It is used to treat a skin problem called dermatitis herpetiformis. Editor,dapsone diaminophenyl sulphone has been in use for many years for the treatment of ocular cicatricial pemphigoid ocp as an antiinflammatory agent. Daviss drug guide for rehabilitation professionals ciccone cd. May 08, 2016 alas, dapsone is not without a downside. Check with your doctor immediately if any of the following side effects occur. It is an antibacterial drug for susceptible cases of leprosy. The steroidsparing effect of dapsone is useful for numerous clinical entities.
Dapsone dosing, indications, interactions, adverse effects. Dapsone is a cyp3a4 substrate and telithromycin is a strong cyp3a4 inhibitor. Dapsone should then be continued for an additional 10 years for borderline patients and for life for lepromatous patients. You should not use dapsone if you are allergic to it. Advise patients to discontinue treatment and seek immediate medical attention with any. Dapsone systemic memorial sloan kettering cancer center. On ehealthme, you can check your drugs with millions of fda reports, or become a member to. Psychiatric reaction to dapsone and sulfapyridine references.
Find information on dapsone aczone in daviss drug guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. As ddsnoh is inevitably formed during dapsone therapy, all these adverse effects are obligatory and vary only in intensity. Are there any other side effects if dapsone is taken for a long time. Hypersensitivity reactions occur in some patients who are on this medication. Dapsone daviss drug guide for rehabilitation professionals. It is a white, odorless crystalline powder, practically insoluble in water and insoluble in fixed and vegetable oils. Dec 24, 2018 our dapsone side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Like other medicines, dapsone can cause some side effects.
Feb 20, 2019 some side effects of dapsone may occur that usually do not need medical attention. The most common side effects of aczone gel are dryness, redness, oiliness, and peeling of the skin being treated. Apr 24, 2019 aczone gel 5% passes into breast milk and may affect a nursing baby. Back, leg, or stomach pains bluish fingernails, lips, or skin difficult breathing fever loss of appetite pale skin skin rash unusual tiredness or weakness rare. Dapsone aczone side effects, dosage, interactions drugs.
Dec 06, 20 as ddsnoh is inevitably formed during dapsone therapy, all these adverse effects are obligatory and vary only in intensity. I know that it is a pretty new approach and can have some bad side effects, so i wanted to see if anyone else has been on dapsone for lyme and get an idea of how it has worked for you. It is used to treat leprosy and the skin condition known as dermatitis herpetiformis. Dizziness, vertigo, blurred vision, and headache have also been reported. Uses, side effects, interactions, pictures, warnings. Dapsone 100 mg daily is continued 3 to 10 years until all signs of clinical activity are controlled with skin scrapings and biopsies negative for one year. It is recommended that regular blood counts be performed during treatment with dapsone. Serious adverse reactions reported in subjects treated with aczone gel, 5%, during clinical. While the safety of use during pregnancy is not entirely clear some physicians recommend that it be continued in those with leprosy. Dapsone is also available as oral pill which has been related to cause hemolytic anemia. Rarely, dapsone can cause numbness and tingling in the hands and feet.
However, many people have no side effects or only have minor side effects. Instruct patient and familycaregivers to report other troublesome side effects such as severe or prolonged headache, sleep loss. If dapsone syndrome occurs rash with fever and eosinophiliadiscontinue immediately may progress to exfoliative dermatitis, hepatitis, hypoalbuminaemia, psychosis and death. Dapsone is an antibacterial medication used in the treatment of dermatitis herpetiformis a skin condition and leprosy hansens disease. It can cause serious side effects, such as anemia, which must be closely monitored during treatment.
Therefore, they will not be dealt with in detail in this survey. Dapsone is used to treat dermatitis herpetiformis a skin condition and leprosy dapsone may also be used for purposes not listed in this medication guide. Dapsone, antiinflammatory mechanisms of action, adverse effects, therapeutic strategies, use in dermatology, nondermatological. Some side effects of dapsone topical may occur that usually do not need medical attention. Aczone gel 5% passes into breast milk and may affect a nursing baby.
Dapsone 100mg tablet via the mouth was one of the first medications used in the treatment of moderate to severe acne, and is still sometimes prescribed for the treatment of severe cases. The adverse drug reactions observed in the study population were type i lepra reactions, gastrointestinal side effects abdominal pain and. Patients may be divided into slow or fast acetylators. There was also no significant difference between the 2 groups in. Dec, 2019 some side effects of dapsone topical may occur that usually do not need medical attention. However, unlike with other medications, no relationship has been seen between acetylator type and side effects.
Aug 25, 2016 my doctor told me to start dapsone this week started a low dose on monday. The peripheral neuropathy is reversible upon discontinuation of dapsone. Also, your health care professional may be able to tell you about ways to. Furthermore, horowitz says, there are many unanswered questions about the use of persister drugs such as dapsone to treat chronic lyme, and much more research is needed. A dose of approximately 1 to 4 g daily is typically required for good control. Dapsone is an antibacterial in the sulfone family of antibiotics. Agranulocytosis, motor neuropathy, and dapsone hypersensitivity syndrome are some of the severe idiosyncratic effects that can occur in patients treated with dapsone. In past decades, especially the hematological adverse effects of. Nervous system side effects have included peripheral neuropathy and manifested predominantly as motor deficits, but in up to 40% of cases, also included sensory loss. Our dapsone side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Like all drugs, there are potential serious side effects. This is not a complete list of side effects and others may occur.
Find information about common, infrequent and rare side effects of dapsone oral. It may be combined with dapsone for cumulative effects without additive side effects. Dapsone dapsone dose, indications, adverse effects. If experienced, these tend to have a severe expression. Deficiency of granulocytes a type of white blood cell. Feb 06, 2020 drug information on aczone dapsone topical includes side effects, uses, drug interactions, dosage, drug pictures, overdose symptoms, and what to avoid. If you have questions about this medicine talk to your doctor, pharmacist, or health care provider.
When treating leprosy, this medication is used along with other medications for at least 6 months. Drug information on dapsone includes side effects, uses, drug interactions, dosage, drug pictures, overdose symptoms, and what to avoid. Common side effects of aczone gel, topical include. Pdf hidradenitis suppurativa hs is an inflammatory skin disease with a chronic intermittent course. Instruct patient and familycaregivers to report other troublesome side effects such as severe or prolonged headache, sleep loss, mood changes, blurred vision, ringingbuzzing in the ears tinnitus, or throat. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Dapsoneusp, 4,4diaminodiphenylsulfone dds, is a primary treatment for dermatitis herpetiformis. Check with your doctor as soon as possible if you have any problems while taking dapsone, even if you do not think the problems are connected with the medicine or are not listed in this leaflet. Allergy to dapsone can cause fever, a rash and swelling of glands in the neck, armpits and groins lymphadenopathy. The starting dose of sulfapyridine is 500 mg twice daily, which is increased by 1 g every 12 weeks until the condition is under control. This leaflet has been written to help you understand more about dapsone. This medicine should be used with caution in patients with severe anemia or glucose6phosphate deficiency or methemoglobinemia due to the increased risk of hemolytic anemia.
See what others have said about dapsone, including the effectiveness, ease of use and side effects. It is also used as a secondline medication for the treatment and prevention of pneumocystis pneumonia and also in the prevention of toxoplasmosis in those patients who have poor immune function. Glucose6phosphate dehydrogenase g6pd deficiency anemia. Dapsone aczone is a prescription antibiotic used for treating acne, leprosy, certain lung and brain infections associated with hivaids, and skin infections. Side effects are rare with dapsone and include mild hemolysis and dapsone allergy, occurring within the first few months of treatment. Dapsone usp, 4,4diaminodiphenylsulfone dds, is a primary treatment for dermatitis herpetiformis. Dapsone is the medication that most commonly causes methemoglobin, but other offending drugs include the local anesthetics benzocaine and lidocaine. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about. Moderate coadministration of dapsone with tetracaine may increase the risk of developing methemoglobinemia. Other side effects include liver inflammation and a number of types of skin rashes.